Endocrine Abstracts

Introduction: Paragangliomas are rare tumors originated from extraadrenals chromaffin cells. Most are sporadic, but between 30% and 50% are associated with hereditary syndromes. Mutations in the succinate gene dehydrogenase (SDH) have been identified as a cause of the hereditary paraganglioma-pheochromocytoma syndrome.Material and methods: Descriptive study of case series of patients belonging to the Southern Health Area of Seville with mutations in the ...

Background: The finding of severe hyperandrogenemia, rapidly progressive clinical hyperandrogenism, defeminization and/or virilization in women of any age should raise the suspicion of an ovarian or adrenal malignancy. Similarly, moderate to severe hyperandrogenemia after menopause, and its clinic consequences, force clinicians to rule out a tumoral source.Matherial and methods: Observational cross-sectional study conducted in patients derived to our cli...

Introduction: Amyloidosis is a rare systemic disease of unknown etiology characterized by the extracellular deposition of proteinaceous (amyloid) material in different organs of the body. About 40-50% are of secondary cause (Amyloidosis AA) Amyloid goiter is a rare condition, usually associated with the secondary form.Case: We reported a 41-year-old male with a history of non-steroidal anti-inflammatories, high blood pressure and smoking habit. Maintains...

Objectives: To evaluate the prevalence in our work center of pathology of adrenal glands and to assess the efficacy of the radiology imaging in the detection of especific features and to exclude malignancy lessions.Material and Methods: We included patients who presented some adrenal lesion with histological study after surgerie between January 2010 and December 2015 in the hospitals of Albacete, Almansa and Villarrobledo. We use the Pathological Anatomy...

Background: Multiple endocrine neoplasia type 1 (MEN1) (OMIM 131100) is an autosomal dominant disorder associated with a high risk of developing parathyroid hyperplasia (90%), digestive neuroendocrine tumors (30–70%) and pituitary adenomas (30-40%). Prevalence of MEN1 is 2-10/100.000, there are no differences between men and women and usually, it is diagnosed before 40 years old. It is related to different mutations of the MEN1 tumour-suppressor gene (OMIM: 613733) which ...

Introduction: There are known biological differences between men and women in coronary heart disease. It is important to know these differences in order to avoid inequalities in prevention, diagnosis and treatment of this pathology.Methods: We designed a retrospective, descriptive study in which we included all diabetic patients admitted to 3 different hospitals in Cádiz province with acute coronary syndrome and diabetes in 2016. Demographic data an...

Introduction: Persistent hyperinsulinemic hypoglycemia may be caused either by a solitary tumor of the pancreas secreting excessive amount of insulin, known as insulinoma or, rarely, by nesidioblastosis. Nesidioblastosis is a rare cause of persistent hyperinsulinemic hypoglycemia in adults.Methods: We describe the case of a 25-year-old male patient who was referred to our clinic for repeted hypoglycemia episodes.Results: Our patien...

Introduction: MODY 5 is a rare type of dominantly inherited diabetes mellitus. It is asociated with mutations of the hepatocyte nuclear factor-1beta (HNF-1beta) gene. They are mostly missense mutations that produce truncated proteins with a variable clinical spectrum that encompasses among others: kidney, genital and pancreatic abnormalities.Case-report: A 35 years-old man without relevant medical history, presented with acute hypergycemia (541 mg/dl) an...

Backgrounds and aims: The aims of the study were, on the one hand, to analize the prevalence of type 2 diabetes mellitus in a population of institutionalized older people and, on the other hand, to evaluate if the anthropometric parameters and the prevalence of malnutrition and sarcopenia were different in diabetic patients compared with the group of non-diabetics.Methods and material: A total of 312 institutionalized elderly people volunteers with a mea...

Introduction: Reports of pregnancy occurring in acromegalic patients are uncommon. Nevertheless, it appears that women are usually able to carry their pregnancy to full termCase: 39 year old woman referred to endocrinology for secondary amenorrhea and hyperprolactinemia (PRL 55.54 mg/dl). As she mentioned typical symptoms of Acromegaly, we extended the study, finding high levels of IGF1 and a pituitary macroadenoma (25×16 mm) in MRI. Presurgical tre...